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promyelocytic (M3) acute leukaemia; a variety of individuals Specific an strange morphologic spectrum intermediate in between M2 and M3 AML.

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superior charge of ordinary or dystrophic promyelocytes in peripheralblood and in bone marrow; no intracytoplasmic Auer rods; myeloperoxydasereaction good; immunocytochemical detection with an anti-PLZF exhibits adistinct punctate nuclear distribution of your protein, suggesting itscompartmentalization within the nucleus.

Swift detection of prognostically considerable fusion transcripts in acute leukemia making use of simplified multiplex reverse transcription polymerase chain response.

ZBTB16-RARα variant of acute promyelocytic leukemia with tuberculosis: a situation report and review of literature.

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Effective allogeneic bone marrow transplantation in the scenario of variant acute promyelocytic leukemia with ZBTB16-RARA.

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A situation of acute promyelocytic leukaemia with unconventional cytological features in addition to a ZBTB16-RARA fusion gene.

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Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia.

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the translocation requires a breakpoint within the zinc fingerregion of PLZF, with fusion of two zinc fingers for the RARa B region toform a five PLZF - three RARa fusion gene; the reciprocal 5 RARa - three PLZF genefuses seven zinc fingers for the RARa region; RARas breakpoint takes place in1- due to thealternative splicing of PLZF gene, two kinds of PLZF-RARa protein could be detected: